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Catalpol exhibits neuroprotective results throughout a number of neurologic circumstances



Catalpol exhibits neuroprotective results throughout a number of neurologic circumstances

Asserting a brand new publication for Acta Materia Medica journal. Neurologic issues are the main explanation for sickness and incapacity on account of elevated life expectancy and international inhabitants getting older, highlighting the pressing want and nice problem for locating neuroprotective brokers with higher efficacy and minimal side-effects.

Catalpol, an iridoid glycoside derived from Rehmanniae Radix, has therapeutic potential in neurologic illnesses on account of its numerous organic actions. This evaluate summarizes the analysis advances and therapeutic potential of catalpol for a variety of neurologic issues, together with melancholy, cognitive impairment, stroke, Parkinson’s illness, and a number of sclerosis.

A complete dialogue of experimental fashions used, dosages, period of remedy, and mechanisms concerned is supplied. The frequent mechanisms underlying the neuroprotective results of catalpol on these neurologic issues are intently associated to antioxidant, anti-neuroinflammatory, and anti-apoptotic properties, in addition to the capability to advertise neuroplasticity and neurogenesis.

Regardless of the promising outcomes from experimental research, there are nonetheless challenges to be addressed, corresponding to figuring out direct binding targets, assessing toxicologic results, and understanding pharmacokinetics. Moreover, well-designed and managed medical trials must be carried out to validate the efficacy and security for treating numerous neurologic circumstances. This evaluate offers compelling proof supporting catalpol as a promising pure neuroprotective agent.

Supply:

Journal reference:

Li, W & Zhou, X., (2025) Catapol: a promising pure neuroprotective agent for neurologic issues. Acta Materia Medica. doi.org/10.15212/AMM-2024-0097.

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