Endometriosis raises the chance of untimely menopause in ladies

Ladies who are suffering from endometriosis have an elevated threat of untimely and early menopause, each naturally and surgically, College of Queensland researchers have discovered.

A complete worldwide research discovered ladies with endometriosis are at 7 occasions the chance of surgical menopause (involving the removing of each ovaries) and face a better threat of untimely menopause (earlier than age 40) or early menopause (between ages 40-44).

Dr. Hsin-Fang Chung, from UQ’s Faculty of Public Well being, mentioned whereas it was identified that endometriosis and its therapy can scale back egg high quality and amount, analysis on its impact on the timing of menopause was restricted.

We discovered surgical menopause occurred, on common,19 months earlier in ladies with endometriosis, whereas pure menopause occurred 5 months earlier.

Ladies with endometriosis are twice as more likely to expertise surgical menopause beneath the age of 40, or 1.4 occasions extra more likely to have pure menopause earlier than 40.”

Dr. Hsin-Fang Chung, UQ’s Faculty of Public Well being

Senior creator, Professor Gita Mishra, mentioned it was already identified early and surgical menopause have been associated to adversarial outcomes comparable to heart problems and untimely demise.

“Stopping or managing early or medically induced menopause requires a complete understanding of its underlying causes and proactive measures to deal with the long-term well being dangers related to it,” Professor Mishra mentioned.

The research – which analysed information from practically 280,000 ladies in Australia, the UK, Sweden and Japan between 1996 and 2022 – is the biggest to look at the kind and timing of menopause in ladies with endometriosis.

The analysis is a part of InterLACE, a global collaboration analyzing ladies’s reproductive well being and power illness throughout their lifetime. 

Endometriosis is a power and sometimes debilitating inflammatory illness, affecting 1 in 7 Australian ladies, the place tissue much like the liner of the womb grows in different components of the physique.

Dr. Chung mentioned she hoped the proof would inform updates to endometriosis administration tips, emphasising the significance of long-term monitoring of the situation.

“Ladies with endometriosis ought to be conscious that they might be at elevated threat of early or induced menopause, go to their GP commonly to test for power illness threat elements, and give attention to prevention methods,” she mentioned.

Dr. Chung’s subsequent step is to analysis the affect of endometriosis on long-term power illness dangers.

The findings can be offered on the sixteenth World Congress on Endometriosis in Sydney later this month.

The analysis is revealed in Human Replica.